@TechReport{	  it:2006-001,
  author	= {Lars Ferm and Per L{\"o}tstedt},
  title		= {Numerical Method for Coupling the Macro and Meso Scales in
		  Stochastic Chemical Kinetics},
  institution	= {Department of Information Technology, Uppsala University},
  department	= {Division of Scientific Computing},
  year		= {2006},
  number	= {2006-001},
  month		= jan,
  abstract	= {A numerical method is developed for simulation of
		  stochastic chemical reactions. The system is modeled by the
		  Fokker-Planck equation for the probability density of the
		  molecular state. The dimension of the domain of the
		  equation is reduced by assuming that most of the molecular
		  species have a normal distribution with a small variance.
		  The numerical approximation preserves properties of the
		  analytical solution such as non-negativity and constant
		  total probability. The method is applied to a nine
		  dimensional problem modelling an oscillating molecular
		  clock. The oscillations stop at a fixed point with a
		  macroscopic model but they continue with our two
		  dimensional, mixed macroscopic and mesoscopic model.}
}